These studies underscore the paradoxical role of arginine metabolism and availability depending on the circumstances (e.g., immune cells infiltration and the type of arginine metabolizing enzymes expressed in these cells in the TME) and type of tumor, implying that arginine supplementation might be interesting for some, but not other tumors (Table 3)
Its mechanism of action involves the direct inhibition of the transcription factor NF-B, a central regulator of the inflammatory response
[DOI] [PubMed] [Google Scholar] 79.Brass E.P., Adler S., Sietsema K.E., Hiatt W.R., Orlando A.M., Amato A
Lessons from (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an inhibitor of receptor tyrosine kinase c-Met with high protein kinase selectivity but broad phosphodiesterase family inhibition leading to myocardial degeneration in rats
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